In 1933 the American people came to their senses and repealed the 18th amendment, which would once again allow the consumption of alcohol in the USA.
However in 1914 Congress had passed the Harrison Act which would only allowed doctors to dispense drugs. No longer able to buy and self-medicate addicts went to doctors who would treat them for their addiction. But in 1919 the Supreme Court ruled that drug addiction was not a disease and doctors could no longer do that and the illegal drug trade began to flourish!
Now unfortunately just saying no wasn’t ever going to work and the legalization of marijuana is a good first step. That is of course as long as all of the tax revenue raised from its sale is going to be spent on the treatment of drug and alcohol addiction. Otherwise all we’ve done is to make the problem even more unwinnable!